[3H]Adenosine Triphosphate: Release during Stimulation of Enteric Nerves

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Science  23 Jul 1971:
Vol. 173, Issue 3994, pp. 336-338
DOI: 10.1126/science.173.3994.336


The isolated taenia coli of the guinea pig takes up tritiated adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, in preference to tritiated inosine and adenine. After uptake, [3H]adenosine is converted and retained primarily as [3H]adenosine triphosphate. Tritium is released from taenia coli treated with [3H]adenosine upon activation of the nonadrenergic inhibitory nerves. These results are consistent with the previous evidence that adenosine triphosphate may be the transmitter from the nerves.