Ribosome-Catalyzed Polyester Formation

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Science  23 Jul 1971:
Vol. 173, Issue 3994, pp. 340-343
DOI: 10.1126/science.173.3994.340


Deamination of phenylalanyl-transfer RNA with nitrous acid yields the α-hydroxyacyl analog, phenyllactyl-transfer RNA. When this is incubated in a protein-synthesizing system directed by polyuridylic acid, it yields an acid-precipitable, alkali-labile polyester of phenyllactic acid.