Inhibitors of DNA Polymerases of Murine Leukemia Viruses: Activity of Ethidium Bromide

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Science  30 Jul 1971:
Vol. 173, Issue 3995, pp. 441-443
DOI: 10.1126/science.173.3995.441


Ethidium bromide, compared on a molar basis, was a more effective inhibitor of the DNA polymerases of the Rauscher and Moloney murine leukemia viruses than either 4-N-demethylrifampicin or 4-N-benzyldemethylrifampicin. Daunomycin inhibited the polymerases weakly, and chromomycin A3 inhibited almost not at all. 4-N-Benzyldemethylrifampicin was a more active inhibitor than the 4-N-demethyl congener.