Reports

Calcium as a Mediator of Adrenocorticotrophic Hormone Action on Adrenal Protein Synthesis

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Science  30 Jul 1971:
Vol. 173, Issue 3995, pp. 447-450
DOI: 10.1126/science.173.3995.447

Abstract

Calcium stimulates leucine incorporation into protein during incubations of sections and cell-free preparations of the rat adrenal. Like adrenocorticotrophic hormone (ACTH) action, calcium enhances the transfer of amino acid from transfer RNA to protein. Stimulation of leucine incorporation by ACTH and cyclic adenosine monophosphate is best observed when sections are incubated in limiting calcium concentrations.