Oxidative N-Dealkylation: A Mannich Intermediate in the Formation of a New Metabolite of Lidocaine in Man

Science  06 Aug 1971:
Vol. 173, Issue 3996, pp. 544-546
DOI: 10.1126/science.173.3996.544


Evidence is presented for a new metabolite of lidocaine. Its structure,N1-ethyl-2-methyl-N3-(2,6-dimethylphenyl)-4-imidazolidinone, suggests reactive electrophilic intermediates for the oxidative removal of N-alkyl groups in general.