Variation and Homology in the Mu and Gamma Heavy Chains of Human Immunoglobulins

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Science  13 Aug 1971:
Vol. 173, Issue 3997, pp. 629-633
DOI: 10.1126/science.173.3997.629


Sequence analysis of an 1gM immunoglobulin shows that the variable regions of hunman µ and γ1 heavy chainis may have twice as much homology as their constant regions and that evolutionary divergence of µ and γ1 heavy chain genes occurred not long after the separation of heavy and light chain genes.