Biological Activity and Synthesis of an Encephalitogenic Determinant

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Science  20 Aug 1971:
Vol. 173, Issue 3998, pp. 736-738
DOI: 10.1126/science.173.3998.736


A 45-residue fragment of the basic protein of myelin is encephalitogenic in the rabbit and monkey but relatively inactive in the guinea pig. Synthetic peptides containing the sequence of a tryptic peptide of the fragment Thr-Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys are moderately encephalitogenic.