Origin of 5-Hydroxyindoleacetic Acid in the Spinal Fluid

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Science  20 Aug 1971:
Vol. 173, Issue 3998, pp. 738-740
DOI: 10.1126/science.173.3998.738


5-Hydroxyindoleacetic acid applied intracisternally in cats does not appear in spinal fluid. Changes of 5-hydroxyindoleacetic acid concentration in the spinal cord are clearly reflected in the perfusate of the spinal subarachnoid space. Thus, 5-hydroxyindoleacetic acid in the spinal fluid originates from the spinal cord and reflects metabolic changes of 5-hydroxytryptamine in the spinal tissue, but not those in the brain.