Cyclic 3',5'-Nucleotide Phosphodiesterase: Cytochemical Localization in Cerebral Cortex

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Science  20 Aug 1971:
Vol. 173, Issue 3998, pp. 745-747
DOI: 10.1126/science.173.3998.745


The distribution of cyclic 3',5'-nucleotide phosphodiesterase activity in rat cerebral cortex was determined by cytochemical methods. The detectable phosphodiesterase activity was localized in postsynaptic (dendritic) nerve endings, most of it immediately adjacent to the synaptic membrane. Most of the postsynaptic nerve endings showed phosphodiesterase activity.