Leucylglycinamide Released from Oxytocin by Human Uterine Enzyme

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Science  27 Aug 1971:
Vol. 173, Issue 3999, pp. 827-829
DOI: 10.1126/science.173.3999.827


Uteri of pregnant and nonpregnant women contain enzymic activities which inactivate oxytocin. A potent enzyme, which has been partially purified from uterine homogenates, cleaves the prolyl-leucyl peptide bond of oxytocin. This findinig associates for the first time the release of the dipeptide leucylglycinamide with the degradation of neurohypophyseal hormones.