Human Fetal Cerebellar Cortex: Organization and Maturation of Cells in vitro

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Science  27 Aug 1971:
Vol. 173, Issue 3999, pp. 829-832
DOI: 10.1126/science.173.3999.829


Human fetal cerebellar cortex was maintained up to 5 months in vitro. Important features included early migration of granule neurons followed by maturation of Purkinje and granule neurons. Unique areas of organization developed in which a rim of leptomeningeal cells surrounded an explant and its outgrowth zone; these areas subsequently grew as well-defined units.