L-Dopa: Disaggregation of Brain Polysomes and Elevation of Brain Tryptophan

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Science  27 Aug 1971:
Vol. 173, Issue 3999, pp. 833-835
DOI: 10.1126/science.173.3999.833


One hour after administration of L-dopa (50 to 300 milligrams per kilogram), there is a marked disaggregation of brain polysomes in immature rats. Adult animals show a similar response, but require larger doses of the amino acid (500 milligrams per kilogram). Single doses of L-dopa significantly elevate amounts of tryptophan in the brain; hence their effect on polysomes does not result from the unavailability of this amino acid.