Pineal N-Acetyltransferase Activity: Effect of Sympathetic Stimulation

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Science  27 Aug 1971:
Vol. 173, Issue 3999, pp. 839-840
DOI: 10.1126/science.173.3999.839


Stimulation of preganglionic sympathetic fibers to the superior cervical ganglia elevates the activity of pineal N-acetyltransferase. After the stimulation-induced rise in enzyme activity, a return toward baseline levels occurs whether or not nerve stimulation is continued. The ability of pineal N-acetyltransferase activity to fall in the presence of stimulation may account for the persistence of its rhythm in blinded animals.