Effects of Long-Term Reserpine Treatment on Brain Tyrosine Hydroxylase and Behavioral Activity

Science  27 Aug 1971:
Vol. 173, Issue 3999, pp. 847-849
DOI: 10.1126/science.173.3999.847


Treatment of rats with reserpine (for 8 or 9 days) produced a temporally related increase in behavioral activity and in tyrosine hydroxylase activity in the midbrain. Weight loss resulting from such treatment was not sufficient, by itself, to account for either the behavioral or enzymatic changes. The results support the role of catecholamines in behavioral arousal.