Homograft Rejection Delayed by Treatment of Donor Tissue in vitro with Antilymphocyte Serum

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Science  03 Sep 1971:
Vol. 173, Issue 4000, pp. 921-923
DOI: 10.1126/science.173.4000.921


Treatment of rabbit corneal tissue in vitro with pooled rabbit serum delays the onset of corneal homograft rejection in the host. Addition of antilymphocyte serum results in a further significant delay in the onlset of rejection. The mechanisms by which such treatment of donor tissues may modify the antigenic content of the material are discussed.