Serum Dopamine-β-Hydroxylase: Decrease after Chemical Sympathectomy

Science  03 Sep 1971:
Vol. 173, Issue 4000, pp. 931-934
DOI: 10.1126/science.173.4000.931


Dopamine-β- hydroxylase is an enzyme that is localized to catecholamine-containing vesicles in sympathetic nerves and the adrenal medulla, and is also found in the serum. Treatment of rats with 6-hydroxydopamine, a drug which destroys sympathetic nerve terminals, leads to a decrease in serum dopamine-β-hydroxylase activity. The decrease is not due to an effect on the adrenal medulla or to an increase in circulating inhibitor or inhibitors of enzyme. These data represent evidence that at least a portion of the circulating dopamine-β-hydroxylase activity arises from sympathetic nerve terminals.