[3H]Lysergic Acid Diethylamide:Cellular Autoradiographic Localization in Rat Brain

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Science  10 Sep 1971:
Vol. 173, Issue 4001, pp. 1022-1024
DOI: 10.1126/science.173.4001.1022


Intravenous administration of [3H]lysergic acid diethylamide(LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Autoradiographic methods were used to differentiate free and bound [3H]LSD in brain tissue.Free [3H]LSD was generally distributed in the pituitary and pineal glands, cerebellum, hippocampus,and choroid plexus.Bound [3H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla,as well as in choroid plexus epithelium.