Phosphatidylserine: Selective Enhancer of Histamine Release

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Science  10 Sep 1971:
Vol. 173, Issue 4001, pp. 1034-1035
DOI: 10.1126/science.173.4001.1034


Phosphatidylserine, in contrast with other phospholipids, markedly enhanced histamine release from rat peritoneal mast cells induced by dextran or protein antigens. This enhancing effect was selective for dextran and protein antigens and did not extend to the action of compound 48/80 or chymotrypsin. These findings suggest a role for phosphatidylserine in the response of mast cells to antigens.