Mineral Element Correlation with Adenohypophyseal-Adrenal Cortex Function and Stress

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Science  10 Sep 1971:
Vol. 173, Issue 4001, pp. 1035-1036
DOI: 10.1126/science.173.4001.1035


A statistical correlationl was made between adrenocorticotropin (ACTH) and four elements in rats under control, stress, and stress-recovery conditions. Blood serum zinc showed a strong positive correlation with the rise in ACTH during stress and its decline in stress recovery. Serum calcium, copper, and magnesium demonstrated little correlation with ACTH changes. The strong ACTH-zinc correlation points to an as yet undefined interaction between ACTH and zinc