Lymphocyte DNA Synthesis Inhibition

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Science  17 Sep 1971:
Vol. 173, Issue 4002, pp. 1139-1141
DOI: 10.1126/science.173.4002.1139


A specific endogenous inhibitor for lymphocyte DNA synthesis that can be isolated from the lymphoid system and which is probably cell specific is described. The inhibitor is thermolabile, is destroyed by trypsin, and has a mass of about 30,000 to 50,000 daltons.