Selective Recovery from Retrograde Amnesia Produced by Hippocampal Spreading Depression

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Science  17 Sep 1971:
Vol. 173, Issue 4002, pp. 1149-1151
DOI: 10.1126/science.173.4002.1149


Injections of potassium chloride into the hippocampus after learning produce temporary disruption of neural activity and retrograde amnesia. Recovery from the amnesia is selective—rats recover from amnesia of events that occurred24 hours before injection but do not recover from amnesia of events that occurred 10 seconds before injection.