Linkage of Genes Controlling the Rate of Synthesis and Structure of Aminolevulinate Dehydratase

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Science  24 Sep 1971:
Vol. 173, Issue 4003, pp. 1245-1246
DOI: 10.1126/science.173.4003.1245


The rate of synthesis of δ-aminolevulinate dehydratase in mice is controlled by alleles at the levulinate (Lv) locus. Two structural mutations modifying the sensitivity of δ-aminolevulinate dehydratase to heat have been identified. Genetic analyses established that the structural locus for δ-aminolevulinate dehydratase was either physically close to or identical with the locus that controls its rate of synthesis.