Persistent Increase in Brain Serotonin Turnover after Chronic Administration of LSD in the Rat

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Science  01 Oct 1971:
Vol. 174, Issue 4004, pp. 62-64
DOI: 10.1126/science.174.4004.62


Lysergic acid diethylamide at doses of 20 micrograms per kilogram per day was administered orally to rats for I month. Eighteen hours after the final dose a 25 to 30 percent increase in the synthesis and turnover of serotonin was noted, as well as a moderate but significant increase in the concentration of tryptophan (18 percent) and serotonin (13 percent) in the brain.