Nonconversion of o,p'-DDT to p,p'-DDT in Rats, Sheep, Chickens, and Quail

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Science  01 Oct 1971:
Vol. 174, Issue 4004, pp. 64-66
DOI: 10.1126/science.174.4004.64


The finding of appreciable quantities of p,p'-DDT after feeding o,p'-DDT to rats led to the proposal of a theory, that an isomeric metabolic conversion occurs. The presence of p,p'-DDT as an impurity in supposedly pure samples of o,p'-DDT is the correct explanation for the appearance of p,p'-DDT. Purified o,p'-DDT and 14C-labeled o,p'-DDT yielded no data to support the idea that o,p'-DDT is converted to the p,p'-DDT isomer.