Methamphetamine-Induced Insulin Release

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Science  01 Oct 1971:
Vol. 174, Issue 4004, pp. 66-68
DOI: 10.1126/science.174.4004.66


Administration of methamphetamine or amphetamine to rats and mice produces a rapid increase in the level of immunoassayable plasma insulin not attributable to hyperglycemia. While in the mouse this release of insulin is followed consistently by a profound hypoglycemia, in the rat this response is variable. Studies in vitro demonstrate that insulin is released by a direct effect of methamphetamine on the pancreas.