Immunochemical Detection of Minor Bases in Nucleic Acids

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Science  01 Oct 1971:
Vol. 174, Issue 4004, pp. 70-72
DOI: 10.1126/science.174.4004.70


Rabbits immunized with bovine serum albumin conjugates of 5-bromouracil, 5-iodouracil, and 6-methyladenosine produced antibodies specific for the bases. These antibodies were used to detect immunochemically 5-bromouracil and 6-methyladenosine in denatured DNA.