Reports

Cyclic Adenosine 3',5'-Monophosphate during Glucose Repression in the Rat Liver

Science  08 Oct 1971:
Vol. 174, Issue 4005, pp. 142-144
DOI: 10.1126/science.174.4005.142

Abstract

Intragastric administration of glucose inhibits the induction of serine dehydratase and tyrosine aminotransferase by glucagon in rat liver, but has no effect on the increase in hepatic adenosine 3',5'-monophosphate resulting from administration of glucagon. Thus, glucose repression in mammalian liver, unlike catabolite repression in microorganisms, appears to operate independently of the amounts of cyclic nucleotide in the cells.

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