Cyclic Adenosine 3',5'-Monophosphate during Glucose Repression in the Rat Liver

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Science  08 Oct 1971:
Vol. 174, Issue 4005, pp. 142-144
DOI: 10.1126/science.174.4005.142


Intragastric administration of glucose inhibits the induction of serine dehydratase and tyrosine aminotransferase by glucagon in rat liver, but has no effect on the increase in hepatic adenosine 3',5'-monophosphate resulting from administration of glucagon. Thus, glucose repression in mammalian liver, unlike catabolite repression in microorganisms, appears to operate independently of the amounts of cyclic nucleotide in the cells.