Iron- and Riboflavin-Dependent Metabolism of a Monoamine in the Rat in vivo

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Science  08 Oct 1971:
Vol. 174, Issue 4005, pp. 153-155
DOI: 10.1126/science.174.4005.153


n-Pentylamine enters into intermediary metabolism by the action of monoamine oxidase. [1-14C] Pentylamine injected into rats is rapidly converted to 14CO2. The rate of catabolism decreases progressively in the course of nutritional iron deficiency, reaching about 60 percent of control values in 3 weeks. Feeding with iron yields control levels within 6 days. The catabolism of amyl alcohol, which shares a common pathway with n-pentylamine by way of valeric aldehyde, is not significantly affected by the deficiency. The results demonstrate that the maintenance of normal monoamine oxidase activity in vivo depends upon an adequate supply of dietary iron.