Cyclic Adenosine Monophosphate: Function in Photoreceptors

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Science  15 Oct 1971:
Vol. 174, Issue 4006, pp. 295-297
DOI: 10.1126/science.174.4006.295


Inactivation of adenylate cyclase in outer segments of retinal photoreceptor cells is proportional to the bleaching of rhodopsin. Membranes of the outer segments also contain a particulate, light-insensitive phosphodiesterase of high specific activity. In electrophysiological experiments, application of cyclic adenosine monophosphate along with a methylxanthine mimics the effects of illumination on the photoreceptor cell of the compound eye of Limulus.