Ovulation Induced by Synthetic Luteinizing Hormone-Releasing Hormone in the Hamster

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Science  29 Oct 1971:
Vol. 174, Issue 4008, pp. 511-512
DOI: 10.1126/science.174.4008.511


A synthetic decapeptide, corresponding to the chemical structure of luteinizing hormone-releasing hormone from porcine hypothalami, was tested for the induction of ovulation in golden hamsters that had previously been treated with phenobarbital to prevent spontaneous ovulation. Subcutaneous injection of 0.089 to 0.357 nanomole of this synthetic luteinizing hormone-releasing hormone stimulated release of luteinizing hormone and induced ovulation.