Marihuana: Standardized Smoke Administration and Dose Effect Curves on Heart Rate in Humans

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Science  05 Nov 1971:
Vol. 174, Issue 4009, pp. 589-591
DOI: 10.1126/science.174.4009.589


A spirometer was used to deliver marihuana and placebo smoke to human subjects. This procedure produced linear dose-effect curves on heart rate and replicable dose effects in individual subjects. No differences were observed between experienced and inexperienced smokers in responsiveness to heart rate increases produced by marihuana.