Mendelian and Uniparental Alterations in Erythromycin Binding by Plastid Ribosomes

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Science  12 Nov 1971:
Vol. 174, Issue 4010, pp. 707-709
DOI: 10.1126/science.174.4010.707


Erythromycin binds specifically to the 52S subunit of the chloroplast ribosome of Chlamydomonas reinhardi. A number of erythromycin-resistant mutants whose ribosomes have lost their affinity for the antibiotic have been isolated, but the sedimentation properties of their ribosomes are indistinguishable from those of the wild-type strain. These mutants represent at least three genetic loci. Two of them show Mendelian inheritance, and one of them is inherited in a uniparental manner.