Anemic Stress as a Trigger of Myelogenous Leukemia in Rats Rendered Leukemia-Prone by X-ray

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Science  19 Nov 1971:
Vol. 174, Issue 4011, pp. 833-835
DOI: 10.1126/science.174.4011.833


All of the 128 Sprague-Dawley female rats bled two-thirds of the blood volume at 1, 2, or 3 months after irradiation (50, 170, or 350 roentgens) succumbed to leukemia by 16 months after bleeding. Some nonbled irradiated rats developed leukemia possibly as a result of triggering by a radiation-induced anemia. The threshold leukemogenic x-ray dose is probably below 25 roentgens. Elevated levels of basophils, neutrophils containing the "pseudo-Pelger" type nuclear anomaly, and myeloblasts exhibiting Auer rods seen in these animals were generally not found in earlier models of rat myelogenous leukemia.