Reports

Potassium Ion Release and Enzyme Secretion: Adrenergic Regulation by α-and β-Receptors

Science  03 Dec 1971:
Vol. 174, Issue 4013, pp. 1029-1031
DOI: 10.1126/science.174.4013.1029

Abstract

Epinephrine caused amylase secretion and K+ release in rat parotid slices. Propranolol, which blocks β-receptors, inhibited amylase secretion; phentolamine, which blocks α-receptors, inhibited K+ release. Since enzyme secretion was associated with fusion of secretory granules to the cell membrane and K+ release was associated with vacuole formation, it could be shown that both α- and β-receptors are present in the same exocrine cell. The findings appear to exclude cyclic 3',5'-adenosine monophosphate as an intermediate in the α-receptor response.

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