Detection of an Antigen Associated with Acute Leukemia

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Science  10 Dec 1971:
Vol. 174, Issue 4014, pp. 1136-1137
DOI: 10.1126/science.174.4014.1136


Antiserums to a purified cell membrane component from a Burkitt's lymphoma tissue culture cell line were produced in rabbits. These antiserums were cytotoxic to peripheral white blood cells from 8 of 15 patients with acute leukemia and 5 of 41 relatives, but not to peripheral white blood cells from leukemia patients in clinical remission or from normal individuals. These antiserums appear to be detecting an acute leukemia associated antigen or antigens.