Reports

Environmental Nitroso Compounds: Reaction of Nitrite with Creatine and Creatinine

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Science  24 Dec 1971:
Vol. 174, Issue 4016, pp. 1341-1343
DOI: 10.1126/science.174.4016.1341

Abstract

Creatine reacts with nitrite under acid conditions to produce first sarcosine and then N-nitrososarcosine, which is a weak carcinogen in the rat. Creatinine reacts with acidified nitrite to produce either creatinine-5-oxime or 1-methylhydantoin-5-oxime, depending on reaction conditions. The toxicity and environmental significance of these compounds is not yet known.