Copper on Intrauterine Devices Stimulates Leukocyte Exudation

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Science  14 Jan 1972:
Vol. 175, Issue 4018, pp. 175-176
DOI: 10.1126/science.175.4018.175


Metallic copper in the uterine or abdominal cavities of rats or monkeys stimulates an impressive local exudation of polymorphonuclear leukocytes. This cellular response to copper persists for at least 7 months, without significant local tissue damage or detectable systemic effects on the test animal. This finding provides a possible explanation for the capacity of copper to increase impressively the antifertility effect of polyethylene intrauterine contraceptive devices.