Reports

Copper on Intrauterine Devices Stimulates Leukocyte Exudation

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Science  14 Jan 1972:
Vol. 175, Issue 4018, pp. 175-176
DOI: 10.1126/science.175.4018.175

Abstract

Metallic copper in the uterine or abdominal cavities of rats or monkeys stimulates an impressive local exudation of polymorphonuclear leukocytes. This cellular response to copper persists for at least 7 months, without significant local tissue damage or detectable systemic effects on the test animal. This finding provides a possible explanation for the capacity of copper to increase impressively the antifertility effect of polyethylene intrauterine contraceptive devices.