Antibody-Dependent Lymphoid Cell-Mediated Cytotoxicity: No Requirement for Thymus-Derived Lymphocytes

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Science  14 Jan 1972:
Vol. 175, Issue 4018, pp. 194-196
DOI: 10.1126/science.175.4018.194


The capacity of lymphoid cells from nonsensitized mice to lyse antibody-coated target erythrocytes in vitro does not require the presence of thymus-derived or thymus-dependent lymphocytes. Thus, spleen cells from thymus-deprived mice and spleen cell populations from which thymus-dependent lymphocytes had been removed were fully competent to mediate destruction of antibody-coated target cells. However, prior treatment of spleen cell populations with antibody to κ chains diminished this function, suggesting a role for bone marrow-derived lymphocytes.