Activation of Viruses in Human Tumors by 5-Iododeoxyuridine and Dimethyl Sulfoxide

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Science  14 Jan 1972:
Vol. 175, Issue 4018, pp. 198-199
DOI: 10.1126/science.175.4018.198


Dimethyl sulfoxide added to cultures first treated with 5-iododeoxyuridine increased C-type virus production approximately tenfold in a human rhabdomyosarcoma cell line. 5-Iododeoxyuridine followed by dimethyl sulfoxide also activated a similar C-type virus in a metastatic tumor from a bronchial node taken from a 52-year-old male.