Morphological Transformation in vitro of Human Fibroblasts by Epstein-Barr Virus: Preliminary Observations

See allHide authors and affiliations

Science  14 Jan 1972:
Vol. 175, Issue 4018, pp. 202-203
DOI: 10.1126/science.175.4018.202


Human embryo fibroblasts have undergone morphological transformation in vitro after infection by Epstein-Barr virus. The fibroblasts were maintained in suspension during exposure to the virus, and further treatment with inactivated Sendai virus increased the transformation rate. The transformed cells were large and polygonal and grew in discrete, heaped up, foci.