Crystalline Cholera Toxin and Toxoid

Science  04 Feb 1972:
Vol. 175, Issue 4021, pp. 529-530
DOI: 10.1126/science.175.4021.529


The exo-enterotoxin of Vibrio cholerae has been obtained in crystalline form. A solution of the crystalline protein was equal in potency to the parent pure toxin in both choleragenicity and skin reactivity. Crystals of the natural toxoid, choleragenoid, resemble those of the toxin in appearance. A solution of crystalline choleragenoid was equivalent to the parent preparation in the flocculation test.