Δ9-Tetrahydrocannabinol: Dose-Related Effects on Timing Behavior in Chimpanzee

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Science  04 Feb 1972:
Vol. 175, Issue 4021, pp. 547-550
DOI: 10.1126/science.175.4021.547


Δ9-Tetrahydrocannabinol, at doses within the effective range for humans, was administered orally to chimpanzees with stable, efficient timing performances maintained by multilink chained schedules of food reinforcement. Reinforcements decreased with increasing dose, because of decreased frequencies of total operant timing responses and decreased accuracy of the timing performances which did occur. Higher doses exerted an effect for up to 3 days.