Growth Retardation in Offspring of Female Rats Treated with Morphine Prior to Conception

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Science  11 Feb 1972:
Vol. 175, Issue 4022, pp. 654-656
DOI: 10.1126/science.175.4022.654


Treatment of female rats with morphine sulfate for 5½ or 10 days, prior to drug withdrawal for 5 days and subsequent mating, results in retarded growth of offspring. The effect is not present at birth but appears at 3 to 4 weeks of age. It occurs even though offspring are not exposed to morphine in utero or postnatally. It is not eliminated by cross-fostering and is apparently of prenatal origin