Inhibition of the Renin-Angiotensinogen Reaction by Pepstatin

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Science  11 Feb 1972:
Vol. 175, Issue 4022, pp. 656
DOI: 10.1126/science.175.4022.656


Pepstatin, an N-acylated pentapeptide obtained from culture filtrates of actinomycetes and first characterized as an inhibitor of pepsin, produces inhibition of the renin-substrate reaction both in vitro and in vivo.