Turnover of Molecules Which Maintain the Normal Surfaces of Contact-Inhibited Cells

Science  25 Feb 1972:
Vol. 175, Issue 4024, pp. 905-906
DOI: 10.1126/science.175.4024.905


In confluent cultures normal chick embryo fibroblasts become highty agglutinable by concanavalin A within 6 hours after their synthesis of protein is inhibited by cycloheximide, pactamycin, or emetine. When growing cells are similarly treated, they fail to become more agglutinable. Apparently, molecules which maintain the normal structure of the cell surface must be replaced continually when cell growth is contact inhibited.