Mast Cells from Human Respiratory Tissue and Their in vitro Reactivity

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Science  03 Mar 1972:
Vol. 175, Issue 4025, pp. 1012-1014
DOI: 10.1126/science.175.4025.1012


Human respiratory mast cells, which were obtained coincidentally with diagnostic bronchial brush biopsy, were maintained under conditions for short-term tissue culture. Most mast cells were viable and degranulated on exposure to antibody to immunoglobulin E or to the mast cell degranulating agent compound 48-80. The degranulation of human mast cells is characteristically an intracellular process with no extracellular extrusion of granules.