Tolerance to Sheep Red Cells: Breakage with Thymocytes and Horse Red Cells

Science  03 Mar 1972:
Vol. 175, Issue 4025, pp. 996-997
DOI: 10.1126/science.175.4025.996


Mice rendered tolerant to sheep red cells and then given normal thymocytes, made no antibody when immunized with these cells. When immunized with horse red blood cells, however, they made significant amounts of noncross-reacting antibody to sheep red blood cells. This suggests that antibody-making precursor cells (B cells) which are nontolerant but nonactivatable by specific antigen, may exist in tolerant hosts.