Thymus-Derived Lymphocytes: Humoral and Cellular Reactions Distinguished by Hydrocortisone

See allHide authors and affiliations

Science  10 Mar 1972:
Vol. 175, Issue 4026, pp. 1126-1128
DOI: 10.1126/science.175.4026.1126


Lymphocytes derived from the thymus (T cells) take part in the induction of humoral antibody and also effect cell-mediated graft-versus-host reactions. Preliminary treatment of mice with hydrocortisone caused an inhibition of T-cell function in humoral immunity, while enhancing the graft-versus-host reactivity of the same population of spleen cells. This suggests that different types of T cells participate in cellular and humoral immune reactions.