Nerve Growth Factor: Stimulation of Regenerative Growth of Central Noradrenergic Neurons

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Science  17 Mar 1972:
Vol. 175, Issue 4027, pp. 1251-1253
DOI: 10.1126/science.175.4027.1251


The growth of new axonal sprouts was studied from transected, ascending noradrenergic axons into transplants of iris tissue in the caudal hypothalamus of the rat. A single intraventricular injection of nerve growth factor, given at the time of axonal damage, resulted in an increased formation and growth of new noradrenaline sprouts 7 days later. The effect seemed to be proportional to the administered dose of nerve growth factor.