Paraoxon: Effects on Rat Brain Cholinesterase and on Growth Hormone and Prolactin of Pituitary

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Science  17 Mar 1972:
Vol. 175, Issue 4027, pp. 1256-1258
DOI: 10.1126/science.175.4027.1256


Cholinesterase activity of brain and content of growth hormone and prolactin in the pituitary were compared after short-term (3 days) and long-term (14 days) treatment with paraoxon in male and female rats. Within 3 days cholinesterase activity was reduced to between 5 and 15 percent of that in controls. The content of growth hormone in the pituitary was increased in long-term experiments by 50 percent. This increase in paraoxon-treated animals-suggests a possible role of a cholinergic mechanism in the regulation of growth hormone secretion.